One of my favourite TTRPGs is releasing an expansion that goes from gothic horror heists to a psychedelic 60s sci-fi dystopia inspired by Deathloop, where the dead feed an oversaturated sky
One of the most popular D&D settings is Spelljammer, a supplement that turns your sword & sorcery to space-faring swashbuckling. While it's certainly a tone shift, it's not an unreasonable one—fantasy adventuring and the idea of a great, unexplored frontier have a lot to do with space. Treasure Planet understood this, as does Pathfinder 2e, which also has Starfinder as another setting.
If you're John Harper, creator of TTRPG darling Blades in the Dark, or Tim Denee, tasked with writing a supplement to said system...