The best Nicole build in Zenless Zone Zero centres around using The Cunning Hares' leader to blast enemies with her ether vortexes, grouping them up so other characters can follow up and do some damage. This suitcase-slinging fighter is really good at debuffing enemies, reducing their defense when she hits them with a vortex or her enhanced bullets.
She's also one of only two ether characters in the game, capable of applying the powerful Corruption anomaly, which deals extra ether damage to afflicted enemies on subsequent hits.