‘Super-drug’ 10 times stronger than fentanyl linked to deaths across multiple states

A powerful new synthetic opioid said to be more potent than fentanyl has been linked to dozens of recent deaths in the U.S., prompting warnings from health officials.

Tennessee was an early hotspot, with the state’s health department announcing in March that more than 30 fatal overdoses had been associated with cychlorphine since October 2025.

An April 2026 notice from the White House’s Office of National Drug Control Policy cited at least 41 Tennessee deaths between July 2025 and February 2026 and at least 55 deaths nationally.