The world's most remote inhabited island has an asthma mystery; scientists traced it to just two settlers who arrived in 1817

A remote island, Tristan da Cunha, has become a vital natural laboratory for asthma research. Due to its isolated population descended from a few founders, scientists can more easily pinpoint genetic links to the respiratory condition. A specific gene variant, DENND1B, shows a strong association with asthma on the island, offering crucial insights that could benefit millions worldwide affected by the disease.