In 1987, ophthalmologist Dr. Jean Carruthers noticed her crossed-eye patients' frown lines were vanishing, and Botox accidentally became cosmetic history's biggest hit

Originally developed to address eye disorders such as blepharospasm, Botox has evolved into a key player in the cosmetic industry since its inception in the 1980s. Pioneering ophthalmologists like Jean Carruthers noted the irony when patients seeking treatment for their eyes left with smoother skin instead.