U.S. airstrikes target members of Iranian leadership while retaliation focuses on Israel and American bases in the region

The U.S. and Israel launched a major attack on Iran on Saturday, and President Donald Trump called on the Iranian public to “seize control of your destiny” by rising up against the Islamic leadership that has ruled the nation since 1979. Iran retaliated by launching missiles and drones toward Israel and U.S. military bases in the region.

Some of the first strikes on Iran appeared to hit areas around the offices of Supreme Leader Ayatollah Ali Khamenei. Smoke could be seen rising from...