Brumbies end 26-year jinx with thrashing of Crusaders
In-form loose forward Charlie Cale scored two of the visitors' eight tries in their first win in Christchurch since 2000, ending a losing streak that stretched 12 games.
The Canberra-based side lead the standings after two rounds, having claimed successive bonus point wins.
They are ahead of Australian rivals the New South Wales Waratahs on points differential, while New Zealand's Waikato Chiefs are the third team boasting two wins from two.
The defending champion Crusaders have lost both of their matches.