France picked uncapped Brau-Boirie at centre to face Wales
The 20-year-old will start in the French midfield alongside his Pau teammate Emilien Gailleton, 22, after Bordeaux-Begles pair Nicolas Depoortere and Yoram Moefana were ruled out through injury.
The rest of the starting XV for Sunday's match is identical to the one that thumped Ireland 36-14 in France's tournament opener last week.
Galthie had hinted at pairing the Pau centres against Wales when he played them together with the rest of the starters in training on Tuesday, as Depoortere and Moefana sat out.