The eureka moment that drove Oprah to reframe weight loss and banish shame involved a Post-It

Oprah Winfrey at the American Ballet Theatre Gala on October 22, 2025.

Lanna Apisukh/WWD via Getty Images

• Oprah Winfrey has been a weight-loss icon for decades and has always carried some shame — until now.
• She recently reframed her own weight loss and now says she'll be on obesity medication for life.
• A new book, co-written with Dr. Ania Jastreboff, unpacks how the disease works.

Dr. Ania Jastreboff has channeled the mindset shift that Oprah Winfrey has publicly undergone into one word ...