Study reveals how rapidly weight comes back after quitting obesity medications

Discontinuing the use of GLP-1 weight-loss medications triggers weight regain more than previously thought, a new study suggested.

The research, which was published in The BMJ, found that stopping the drugs is also associated with a reversal of improvements in heart and metabolic health, including cholesterol and blood pressure.

University of Oxford researchers analyzed 37 studies published up to February 2025, involving more than 9,000 participants who had undergone an average of 39 weeks of weight-loss treatment.