Astronauts from US, India, Poland, Hungary bound for Earth
Axiom Mission 4, or Ax-4, undocked from the orbital lab at 7:15 am ET (1115 GMT) on Monday, beginning a 22.5-hour journey back to Earth.
Splashdown is scheduled for 5:31 ET (0931 GMT) in the Pacific Ocean on Tuesday.
"Thank you very much for your support. You guys are amazing," Commander Peggy Whitson, an Axiom employee and former NASA astronaut, told flight controllers in Houston.
Also aboard are pilot Shubhanshu Shukla of India and mission specialists Slawosz Uznanski-Wisniewski of Poland and Tibor Kapu of Hungary.