Fritz into Wimbledon quarter-finals after Thompson retires
The US fifth seed faced gruelling five-set battles in his opening two matches but it was a different story in his fourth-round encounter on Court One.
The Eastbourne champion broke Thompson twice to seal the first set in just 21 minutes and led 3-0 in the second set.
The Australian then had a medical time-out to deal with an apparent thigh problem.
He returned to the court and slipped 40-0 down in the fourth game before deciding he was unable to continue, with the match lasting just 41 minutes.