Closing arguments: Is Karen Read’s murder trial a tale of love gone wrong or a police coverup?

Lawyers in the murder trial of Karen Read are set to give their closing arguments Friday after weeks of testimony in a highly divisive case in which the prosecution’s theory of jaded love turned deadly is countered by a defense claim that a cast of tight-knit Boston area law enforcement killed a fellow police officer.

Read, 45, is accused of fatally striking her boyfriend, Boston police officer John O’Keefe, 46, with her SUV and leaving him to die in the snow outside a house party where...