Messi, Inter Miami CONCACAF Cup dream over as Vancouver advance
The Whitecaps will meet the winners of Thursday's other semi-final between Mexican clubs Cruz Azul and Tigres UANL which stands at 1-1 ahead of the second leg.
Trailing 2-0 from the first leg, Miami made the perfect start to their comeback attempt when former Spain international Jordi Alba put them ahead on the night in just the ninth minute.
Messi, from midfield, threaded the ball through to Luis Suarez who found Alba on th left and his low drive got through Japanese keeper Yohei Takaoka at his near post.