Shaquille O'Neal runs off TV set to use bathroom in hilarious on-air scene: 'He can't hold it'

Shaquille O’Neal’s need to use the restroom on "Inside the NBA" sparked massive laughter and confusion among his co-workers, Ernie Johnson, Kenny "The Jet" Smith and Charles Barkley. 

And yes, it was during a live segment. 

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While analyzing the Denver Nuggets-Los Angeles Clippers Game 2 slate in the NBA Playoffs' first round, O’Neal got up fast off his chair and started to make his way to the door. Johnson, Smith and Barkley were all stunned.