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MONACO — Second-ranked Alexander Zverev lost 2-6, 6-3, 7-5 to fellow big-hitter Matteo Berrettini in the second round of the Monte Carlo Masters on Tuesday.

The unseeded Berrettini secured victory when serving for the match for the second time and on his first match point against the top-seeded German.

“I wasn’t hitting my forehand and serve like I had in previous days,” said Berrettini, who has won 17 of his past 18 matches on clay. “I told myself to be more aggressive.”

Zverev...