Possibly, but it doesn't happen very often and it won’t be easy
We might as well deal with it now, unlikely as it may be. Raleigh’s News and Observer already posted a story exploring the possibility. “Can Duke basketball go unbeaten in the ACC?” the headline read on the let’s-be-first-to-print-it article. “Odds are strong; Blue Devils are that good.”
Not sure how strong “the odds” are, though...