49ers’ Brandon Aiyuk (knee), Deebo Samuel (illness) ruled out for second half vs. Chiefs

SANTA CLARA — The 49ers’ already depleted offense has taken two more hits.

San Francisco announced that wide receivers Brandon Aiyuk (knee) and Deebo Samuel (illness) have been ruled out for the second half against the Chiefs at Levi’s Stadium, leaving the 49ers without their top-three receiving options.

Samuel, who the 49ers announced as having an illness prior to kickoff, was initially listed as questionable to begin the second half, but was then downgraded to out following the 49ers’ first drive of the third quarter.