Jim Harbaugh’s Chargers coaching debut one of many season-opener storylines

Chargers quarterback Justin Herbert returns to an NFL field for the first time since suffering a season-ending finger injury in Week 14 last season. Outside linebacker Joey Bosa returns to an NFL field for the first time since suffering a season-ending foot injury in Week 11 last season.

Safety Derwin James Jr. faces off against wide receiver Devante Adams of the Las Vegas Raiders for the first time since the Chargers’ humiliating and franchise-altering 63-21 loss in Week 15 last season.