What is the Whitebeard ‘The One Piece is Real’ meme?

The One Piece Is Real meme is based on a catchphrase shouted by the character Whitebeard from the anime version of One Piece, which was based on the manga of the same name. The phrase is uttered as Whitebeard dies and becomes a meme used in online comments, in addition to being used as part of video edits featuring Whitebeard.

These edits are often set to “Dark Fantasy” by Kanye West, specifically its lyric "can we get much higher." The One Piece is Real meme is also closely tied to the One Piece Cock Edits meme...