'Grey's Anatomy' Cast Shakeup for Season 21: Two Actors Leaving, Many Stars Need to Sign New Contracts

The upcoming 21st season of Grey’s Anatomy is likely going to look a lot different than the current one as the cast is going through a big shakeup.

Two actors have already been confirmed to leave the show, though they will appear in a few episodes next season to wrap up their storylines.

Major changes are also expected for some of the longtime stars of the show. A budget cut for season 21 has led to an episode reduction for lead character, with some of the show’s established stars being guaranteed less episodes.