Weight loss from Wegovy sustained for up to four years, trial shows

Enlarge / Wegovy is an injectable prescription weight loss medicine that has helped people with obesity. (credit: Getty | Michael Siluk)

A large, long-term trial of the weight-loss medication Wegovy (semaglutide) found that people tended to lose weight over the first 65 weeks on the drug—about one year and three months—but then hit a plateau or "set point." But that early weight loss was generally maintained for up to four years while people continued taking the weekly injections.