Chemical tweaks to a toad hallucinogen turns it into a potential drug

Enlarge / The Colorado River toad, also known as the Sonoran Desert Toad. (credit: Mark Newman)

It is becoming increasingly accepted that classic psychedelics like LSD, psilocybin, ayahuasca, and mescaline can act as antidepressants and anti-anxiety treatments in addition to causing hallucinations. They act by binding to a serotonin receptor. But there are 14 known types of serotonin receptors, and most of the research into these compounds has focused on only one of them—the one these molecules like, called 5-HT2A.