On August 16, 1943, Swiss chemist Albert Hofmann was synthesizing a new compound called lysergic acid diethylamide-25 when he got a couple of drops on his finger. The chemical, later known worldwide as LSD, absorbed into his system, and, soon after, he experienced an intense state of altered consciousness. In other words, he tripped.
Intrigued by the experience, Hofmann dosed himself with 250 micrograms of LSD and then biked his way home through the streets of Basel, making him the first person ever to intentionally drop acid.